A recent study conducted by Redcliffe Labs in India has unveiled a crucial association between chromosome variations and recurrent pregnancy loss (RPL). The research identified a notably higher prevalence, reaching up to 33.7 percent, of chromosomal polymorphisms (CPM) among couples grappling with repeated miscarriages and infertility.
Recurrent pregnancy loss, characterized by two or more pregnancy losses, affects approximately 7.4 percent of couples in India, with many cases remaining undetermined in terms of causation. Traditionally, chromosomal polymorphisms were viewed as benign variances. However, this study suggests they may exert a more profound influence than previously recognized.
Involving over 1,400 individuals, including 700 couples clinically diagnosed with recurrent pregnancy loss, the study unveiled a notably elevated presence of chromosome variations in couples experiencing recurrent pregnancy loss, surpassing earlier estimations.
Ashish Fauzdar, Head of Clinical Genomics & Cytogenetics at Redcliffe Labs, commented on the significance of these findings, stating, “While numerous studies on pregnancy loss have been conducted in the Indian subcontinent, we are the first to identify the elevated prevalence of chromosomal polymorphism in couples grappling with recurrent pregnancy loss. This strongly indicates that CPM plays a more substantial role than previously assumed. While further research is warranted, our discoveries will empower healthcare professionals to counsel patients and implement timely clinical interventions for couples planning future pregnancies following unexplained repeated pregnancy loss.”
The researchers emphasize the necessity for additional studies to corroborate this linkage. Nonetheless, these findings offer optimism for couples confronting unexplained pregnancy loss. By acknowledging chromosomal variations as a potential contributor, medical practitioners may be better positioned to steer patients toward successful pregnancies.
