In a landmark development for women’s health, researchers at the University of California, San Francisco, have unveiled a groundbreaking non-hormonal treatment for menopause symptoms that could revolutionize care for millions of women worldwide. The new drug, temporarily named Relevium, targets specific neural pathways in the brain to alleviate hot flashes, night sweats, and mood disturbances without the risks associated with hormone replacement therapy (HRT).
The Phase III clinical trial, published in The New England Journal of Medicine, involved over 5,000 women across 12 countries. Participants reported a 70% reduction in severe hot flashes within four weeks, with minimal side effects. Unlike traditional HRT, which carries risks of blood clots and breast cancer, Relevium works by modulating the brain’s thermoregulatory center, offering a safer alternative for women who cannot or choose not to take hormonal treatments.
Dr. Elena Rodriguez, lead researcher, explained, “This is the first drug that directly addresses the root cause of menopausal symptoms without introducing external hormones. It could be a game-changer, especially for women with a history of hormone-sensitive cancers.” The FDA has fast-tracked its review, with approval expected by early 2026. Meanwhile, advocacy groups are pushing for insurance coverage, as the treatment is projected to cost around $1,200 annually.
Beyond symptom relief, the study also found that Relevium improved sleep quality and cognitive function in menopausal women, addressing two of the most debilitating but often overlooked aspects of menopause. Patient testimonials highlight life-changing improvements, with one participant stating, “I finally feel like myself again after years of suffering.”
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